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How HIV works
Could cell enzyme activity explain variability in response to NRTIs?

HIV infection produces a wide variation in the activity of two cell enzymes that are crucial for nucleoside analogue (NRTI) activity, according to a test-tube

Published
22 March 2005
By
Christopher Gadd
How HIV works
HIV co-receptor use in the blood and central nervous system differs in 20% of patients

HIV from the blood and cerebrospinal fluid of most patients with detectable viral loads uses the same co-receptors to enter cells, according to a study

Published
14 February 2005
By
Christopher Gadd
How HIV works
Low, detectable viral load on HAART associated with high levels of activated CD4 and CD8 T-cells

Two recent studies have helped to explain how patients taking highly active antiretroviral therapy (HAART) but who have low, detectable viral loads can maintain stable

Published
20 January 2005
By
Christopher Gadd
How HIV works
Deoxyhypusine synthase: a new target for HIV therapy?

An inhibitor of the enzyme deoxyhypusine synthase (DHS) can suppress the replication of HIV, according to a test tube study presented in the January edition

Published
12 January 2005
By
Christopher Gadd
How HIV works
Can HIV infection occur through the lining of the mouth?

HIV from semen or breast milk can bind to and infect the cells lining the mouth and the tonsils, according to two test tube studies

Published
01 December 2004
By
Christopher Gadd
How HIV works
Dendritic-cell treatment boosts therapeutic vaccine prospects

A group of French and Brazilian researchers have claimed a possible success in boosting immune responses and controlling HIV in a clinical trial where 18

Published
30 November 2004
By
Julian Meldrum
How HIV works
AZT resistance suppression mutations can also reduce tenofovir resistance, test tube study shows (corrected)

This is a corrected version of an article originally published on aidsmap.com on Friday, 19 November 2004. Mutations in HIV that suppress AZT (zidovudine, Retrovir) resistance,

Published
19 November 2004
By
Christopher Gadd
How HIV works
ICAAC: Mitochondrial DNA level in blood may provide early warning of lipodystrophy

People with low mitochondrial DNA content in their blood after 48 weeks of treatment with either AZT (zidovudine, Retrovir) / 3TC (lamivudine, Epivir) or d4T

Published
30 October 2004
By
Keith Alcorn
How HIV works
AZT & d4T damage fat cells long before fat loss visible

AZT (zidovudine, Retrovir) and d4T (stavudine, Zerit) begin to cause damage to fat cells (adipose cells) long before physical signs of fat wasting appear, according

Published
28 October 2004
By
Keith Alcorn
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